Novak Djokovic attributed his first-round loss to Mariano Navone at the U.S. Open to ongoing health issues, including vomiting, cramping, and significant pain. The loss on Sunday, August 30, marked the 39-year-old's earliest U.S. Open exit of his career.

Djokovic stated that these physical problems have been present in nearly every match this year. During the match, he managed to take a two-sets-to-one lead before his condition deteriorated. He required medical attention as he struggled with his back and shoulder.

"The back just gave up in the end, and the shoulder, and I couldn't close it out,"

Djokovic admitted he considered retiring from the match at certain points. Navone ultimately won the match in five sets. Djokovic did not disclose a specific diagnosis for the recurring symptoms, which include:

• Vomiting
• Cramping
• Back and shoulder pain

Following the match, Djokovic expressed gratitude for the support of the fans at Arthur Ashe Stadium. Speaking to TMZ Sports less than 48 hours after the defeat, he stated he was feeling "a bit better." The loss represents Djokovic's first opening-round defeat at the U.S. Open and his earliest Grand Slam exit in two decades.